142 E Main St Spartanburg, SC 29306 · Phone: 864-583-4521 · Fax: 864-582-0438 · Mon-Fri: 8:30a.m.-6p.m. · Sat: 8:30a.m.-2p.m · Sun: Closed

We're A Local Pharmacy Dedicated To Your Family's Health

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Serving the community since 1930

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Smith's Drug Store is the oldest independent drug store in Spartanburg and a staple among the medical community. While we have always provided medicine at discount prices, offered local delivery service and rendered expert medication advice, what truly separates us from the average pharmacy is our emphasis on the customer experience. Our reputation is, and always has been, built on the foundation that people deserve exceptional service when it comes to their health and medications. This means going above and beyond for our patients and treating them like family. At Smith's Drug Store, we believe that all patients deserve prompt, personalized service from our caring staff of trained professionals. We are dedicated to providing quality pharmaceuticals at a reasonable price. Save time at Smith's Drug Store – no long lines no long waits! We take most major insurances, including Medicare and SC Medicaid. For your convenience, we offer delivery within a 10 miles radius and accept most major credit cards, ATM cards and flexible spending accounts.

Special Services


Home Delivery

We offer home delivery to the nearby Spartanburg area. Contact us for details or to schedule your free delivery.


Durable Medical Equipment

We carry a wide selection of medical equipment, including ambulatory aids, nebulizers and bathroom equipment.

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We offer a variety of vaccines to keep you healthy. Contact us to learn more about our immunizations.


Medication Synchronization

Sync your prescriptions with us and pick up all of your medications on the same day each month.

Download Our Free Mobile App


Refill on-the-go

Refill your medications 24/7 on-the-go or when you're at home.


User Profiles

Safely store your information and manage your list of prescriptions.


Pill and Refill Reminders

Set reminders to take your meds or when it's time to refill.

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p: 864-583-4521

f: 864-582-0438